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The principle of using mAbs to increase IgG catabolism was also demonstrated in NHPs, when Nixon and colleagues at Dyax Corp used phage-display selected human IgG1 mAbs with high pH-independent affinity towards FcRn to reduce circulatory IgG without affecting albumin levels in NHPs [122]

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The exact field labels can vary, but the logic stays the same

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A variety of factors can influence the efficacy of medications, including racial background, gender, genetic makeup, ambient temperature, interactions between different drugs, initiating triggers, neurohormonal fluctuations, the current state and intensity of the disease, and alterations in the bodys structure caused by the disease itself (31)

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