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Deregulation of the signaling pathways controlling urokinase production

139 Guideline Statement 15 Clinicians should counsel patients who are considering pentosan polysulfate sodium on the potential risk for macular damage and vision-related injuries

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Government Securities Fund - Class A WF California Tax Free- Institutional Columbia Seligman Global Technology Fund Class R Columbia Seligman Global Technology Fund Class I2 Western Asset Mortgage Total Return Fund Class A Wells Fargo Government Securities Fund Class A Wells Fargo Government Securities Fd Institutional Cl Western Asset Mortgage Total Return Fund Class 1 SEI Insti Inv Tr Sextant Growth Fund Z Class Stone Harbor Emerging Markets Debt Allocation Fund ClearBridge Appreciation Fund Class A Stone Harbor Emerging Markets Debt Blend Fund Stone Harbor Emerging Markets Corp Deb Fd Insti Cl Western Asset Short Duration Municipal Income Fund Class A American Beacon Shapiro SMID Cap Equity Fund - Institutional Class Western Asset Short Duration Municipal Income Fund Class C American Beacon Shapiro SMID Cap Equity Fund - Investor Class Western Asset Short Duration Municipal Income Fund Class A2 Western Asset Short Duration Municipal Income Fund CL IS American Beacon Shapiro SMID Cap Equity Fund - Y Class CLS Shelter Fund Class T ClearBridge All Cap Value Fund Class A Legg Mason High Growth Fund Class IS Columbia Seligman Global Technology Fund Class A Test Mutual Fund - ACMI Stone Harbor High Yield Bond Fund Insti Cl Western Asset Short Duration High Income Fund Class A Western Asset Short Duration High Income Fund Class C1 Catalyst/Exceed Defined Shield Fund Class A Stone Harbor Investment Grade Fund Catalyst/Exceed Defined Shield Fund Class I Catalyst/Exceed Defined Shield Fund Class C BlackRock HlthSc Op Svc Wells Fargo Heritage Money Fd Inst Cl Western Asset Short Duration High Income Fund Class I USCA Shield Fund - Institutional Class USCA Shield Fund - Investor Class Stone Harbor Local Market Fund Stone Harbor Emerging Debt Fund Insti Cl Western Asset Managed Municipals Fund Class A Wells Fargo Heritage Money Fund Admin Cl AIG Flexible Credit Fund - Class A AIG Flexible Credit Fund - Class C Western Asset New Jersey Municipals Fund Class A AIG Flexible Credit Fund - Class W American Beacon SiM High Yield Opportunities Fd Cl A American Beacon SiM High Yield Opportunities Fd Cl C American Beacon SiM High Yield Opportunities Fd Inst Cl Western Asset Oregon Municipals Fund Class A American Beacon SiM High Yield Opportunities Fd Cl Y Saratoga Advantage Tr Health & Biotechnology Port Cl A Saratoga Advantage Tr Health & Biotechnology Fd Cl C Short Small Cap Profund Short Small Cap Profund ClearBridge Aggressive Growth Fund Class A Western Asset California Municipals Fund Class A Stone Ridge High Yield Reinsurance Risk Premium Fd Cl I Stone Ridge High Yield Reinsurance Risk Premium Fd Cl M Western Asset California Municipals Fund Class IS shares BlackRock HlthSc Op A BlackRock HlthSc Op C Stone Harbor Strategic Income Fund BlackRock Health Sciences Opportunities Portfolio - Class K BlackRock HlthSc Op I Columbia Seligman Global Technology Fund Class C Invesco Short Duration Inflation Protected Fund Cl A2 ABBF-AB Short Duration Income Portfolio - A ABBF-AB Short Duration Income Portfolio - C ABBF-AB Short Duration Income Portfolio - Advisor American Beacon Shapiro Equity Opportunities Fund - Institutional Class American Beacon Shapiro Equity Opportunities Fund - Investor Class American Beacon Shapiro Equity Opportunities Fund - Y Class SEI International Management Tr High Yield Bond Fund Class F Western Asset Global High Yield Bond Fund Class C1 Guggenheim High Yield Fund - Institutional Class Short Duration Municipal Fund Class Y Western Asset Global High Yield Bond Fund Class I American Beacon SiM High Yield Opportunities Fd Inv Cl Guggenheim High Yield Fund Class R6 DWS Strategic High Yield Tax-Free Fund - Class S Sit Balanced Fund Touchstone Balanced Fund Class Y Saratoga Investment Quality Bond Portfolio SEI Asset Allocation Trust Conservative Strategy Fund Cl I Western Asset Intermediate Maturity California Municipals Fund CL IS Schwab International Core Equity Fund Institutional Shs Touchstone Large Cap Focused Fund Class Y Western Asset Intermediate Maturity California Municipals Fund Class I Intermediate Duration Credit Fund Class A Hartford Schroders International Multi-Cap Value Fund (Class I) Hartford Schroders International Multi-Cap Value Fund (Class SDR) Hartford Schroders International Multi-Cap Value Fund (Class A) AIG International Dividend Strategy Fund - Class A Saratoga Advantage Tr

In addition to the cohort studies, four meta-analyses confirmed a higher frequency of vitamin B12 deficiency in patients with T2D taking metformin [28-31]