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Recently, an NADH-binding pocket in voltage dependent anion channels (VDAC) has been proposed as a target to develop small molecules to regulate mitochondrial metabolism ( + also participates in post-translational modification of proteins through ADP-ribosylation reaction (88) and protein deacetylation via sirtuins (89, 90)

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Although most cases are sporadic, 5%10% are associated with genetic or aging-related factors