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Whanger PD

SimesDMMalheirosJAntunesPEFigueirinhaACotrimMDFonsecaDA

However, these combination therapies have not shown a significant increase in overall survival compared to chemotherapy alone [35,36,37,38]

Because of the large amounts of haemoglobin compared with the amount of drug given this would be inconsequential, were it not for the fact that the oxidised active metabolite can be recycled back to the active metabolite by reduction with NADPH (reduced nicotinamide adenine dinucleotide phosphate) in the erythrocyte