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The 3-D cell design was made by culturing cells (2 105-- 1.0 106) with high glucose DMEM supplemented with 30% bovine collagen solution over night

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Researchers do this to equalise pressure, but it introduces airborne contaminants and creates a positive pressure differential that forces solution back through the needle tract on every subsequent draw, accelerating bacterial contamination

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This can be helpful in understanding if you're unable to make ample cortisol or if instead, you are inactivating it to cortisone