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Across these models the recurring theme, where effects are seen, is not that GHK-Cu creates tissue from nothing, but that it appears to influence the normal repair sequence recruitment of fibroblasts, matrix synthesis, cross-linking supported by copper-dependent lysyl oxidase, and angiogenesis

documented that GHK-Cu modulates over 4,000 human genes, including gene sets involved in tissue remodeling, Wnt pathway signaling, and inflammatory regulation

What doesn't work as a primary treatment: tennis ball rolling (comfort, not therapy), heel cups alone without mechanical correction, and long-term NSAID use

Research highlights enhanced wound healing, decreased inflammation, and assistance with hormonal pathways

The strength of evidence depends on the specific application you're considering