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In healthy mitochondria, SIRT3 interacts with ATP5O, while the low pH owing to the loss of membrane potential weakens the binding affinity between SIRT3 and ATP5O, leading to the redistribution of SIRT3 to other mitochondria substrates

The shear stress, representing shear force per unit area, is particularly elevated near the vessel wall with values ranging from 1 to 4 dyn/cm 2 in veins, and 430 dyn/cm 2 in arteries [219]

Arn, G