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E., Irvin, C

1 Introduction Alzheimers disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, memory loss, and behavioral changes, affecting millions of aged individuals worldwide

The first study identified N -acetyl-aspartyl-glutamate (NAAG), which can be hydrolyzed to glutamate when needed by the oncogenic cells via glutamate carboxypeptidase II (GCP II) [41, 42], suggesting that GCPII is a viable target for cancer therapy, either alone or in combination with glutaminase inhibition

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