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AT-1002 alters intestinal permeability in a PAR2-dependent manner with increases in permeability comparable with Zot and zonulin-induced alterations (4143)

The evidence supports neither extreme

doi: 10.1023/A:1016048526475 72

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Patients need to understand what the research suggests, what remains uncertain, and why symptoms such as chronic diarrhea, abdominal pain, blood in the stool, unexplained fatigue, rashes, food reactions, or suspected inflammatory bowel disease deserve proper evaluation

Most of the rest of this chapter is about that 123 km 3 /day of stream and groundwater flow