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110,111 Nonhomologous end joining plays a vital role in the repair of double-strand breaks, particularly in cells that are not actively replicating, by directly connecting the damaged ends of DNA

Changes in the coupling efficiency of receptors to signal transduction pathways and receptor internalization can account for desensitizationand the development of pharmacodynamic

Initial screening of the in vivo activity of the LiTE and Albu-LiTE-HB was investigated in an immunodeficient C57BL/6 RAG1 knockout mouse model inoculated with a 2:1 mixture of HT-29 cells and human PBMCs using multiple (8) drug doses to compensate for the short half-life of the unfused LiTE (Supplementary Fig

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doi: 10.1038/s41590-020-0751-0 206 KlarquistJHenniesCMLehnMARebouletRAFeauSJanssenEM