Even though a promising candidate for lifespan extension and SASP repression, multiple side effects including metabolic dysregulation, impaired wound healing, and hyperlipidemia have been reported (85)
Incollingo Rodriguez AC, Epel ES, White ML, Standen EC, Seckl JR, Tomiyama AJ
[DOI] [PMC free article] [PubMed] [Google Scholar] 12.Paramanya A., Ali A
Contraindications: Active uveal inflammation Most cases of angle-closure glaucoma , due to the possibility of increasing angle block Hypersensitivity to the active or inactive ingredients Side Effects: Retinal detachment has been reported in a few cases Stinging, burning, lacrimation Iris cysts may form Lens opacities Cardiac irregularities Pharmacokinetics: Administered in eye drops to patients with glaucoma ) Forms an irreversible covalent bond with the ACh binding site on cholinesterase (duration of action is ~100 hrs Drug Interactions: Potentiates other cholinesterase inhibitors such as succinylcholine or organophosphate and carbamate insecticides Patients undergoing systemic anticholinesterase treatment should be warned of the possible additive effects References: Merck Manual Professional Edition (2026): Medications Used to Treat Glaucoma
Is affected by social issues that may prevent them accessing care, such as homelessness
This additional step was imperative for conducting direct evaluation of the hypothesis that LASSS interacts/reacts with HGF to augment its c-met binding affinity