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To validate that this synergistic interaction is indeed dependent on mut-p53 and SLC7A11 expression, we next demonstrated that these drug combinations were more effective in H1299 cells overexpressing mut-p53 compared to the p53 Null parental line (Fig

[16,98] A randomized crossover trial in humans looked at the effect of selenium (4000 mcg/day from four days before until four days post-chemotherapy) on the toxicity of cisplatin

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