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Funding This work was supported by the State Committee of Science RA (N 10-14/23-I/YSMU and 20TTCG-3A012) and the EU-funded H2020 COBRAIN project (857600)

Furthermore, the mechanisms and behavioral traits of cell death mediated by cystine deletion have been shown to be similar to those in renal cell carcinoma cells with VHL deletion (13)

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GPR40 receptor activation promotes tight junction assembly in airway epithelial cells via AMPK-dependent mechanisms

46 Hence, the reduction of sirtuins, with its related metabolic alterations, is a major characteristic in senescent cells and associated with the SASP phenotype