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doi:10.1371/journal.pone.0254794 97

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In addition, multiple transcription factors, such as ATF3, ATF4, P53, Nrf2, and c-Myc, have been identified as the regulators of SLC7A11 and SLC3A2 transcription [11, 27,28,29,30]

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Available inducers (e.g., erastin, RSL3, elesclomol) often suffer from poor pharmacokinetics, limited tumor selectivity, and narrow therapeutic windows, leading to potential off-target toxicity