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The Ca 2+ influx facilitates vesicle fusion with the plasma membrane, which releases the neurotransmitters into the synaptic cleft (Figure 2

Neuron 111 , 17481759.e8 (2023)

The open field model was followed to assess the behaviour of animals treated with L-SLNs (2.5 mg/kg, 5 mg/kg, 10 mg/kg)

Neither compound has FDA approval or a completed human efficacy trial, so any comparison should be read as mechanism-to-mechanism, not outcome-to-outcome

While UK healthcare professionals can, in exceptional circumstances, prescribe unlicensed medicines under the MHRA 'specials' framework, this would rarely be appropriate for ED given the availability of licensed, evidence-based alternatives

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