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For Canadians pursuing body recomposition, the challenge has historically been finding interventions that simultaneously promote fat loss while protecting or even building muscle tissue

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The SURMOUNT-1 clinical trial tracked weight loss outcomes across all three maintenance dose tiers over 72 weeks in adults with obesity or overweight

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However, in human research, whether it is pharmacological or neuroimaging, it is not possible to specifically delineate the pathways, hence, here, we collapse the second and the third pathways, referring to them as the mesocorticolimbic pathway

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