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Nevertheless, there is currently a lack of OA-specific genetic models validating the FSP1 or DHODH targets, as well as systematic research on the expression profiles and activity distribution of these pathways in different tissues such as cartilage, synovium, and subchondral bone

759 The E3 ligase RING finger protein 146 (RNF146) is responsible for ubiquitination and degradation of ACSL4

PMID: 30112169