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This is why we overwhelmingly use transdermal forms of estrogen in menopause hormone therapy

Crucially, it has no published controlled human trials at all

doi: 10.1111/j.1476-5381.2009.00125.x 83 HennigB.LeiW.ArzuagaX.GhoshD

Similarly, preclinical research involving animals must comply with Institutional Animal Care and Use Committee (IACUC) directives and adhere to Animal Welfare Act (AWA) standards