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High concentrations of 4HNE have been associated with different processes such as apoptosis, cell differentiation, altered gene expression and with several diseases correlated to redox imbalance such as neurodegenerative and cardiovascular diseases, metabolic syndrome, and cancer 15

Unlike other reviews that may focus solely on the therapeutic effects of MSCs-derived factors in AKI/CKD or cellular senescence independently, this paper specifically highlights the potential of MSC-derived secretome as a novel therapeutic strategy to counteract the senescence, aging, and diseases of the kidney

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Yan LL, Zaher HS (2019) How do cells cope with RNA damage and its consequences