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Moreover, researchers fused TALEN to the Pseudomonas aeruginosa type III secretion system effector ExoS54 signal peptide and a nuclear localization signal, enabling direct cytosolic delivery and subsequent nuclear translocation of functional TALEN protein into human HeLa cells via bacterial injection, achieving targeted knockout of the Venus reporter gene [114]

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Further, we described that LDHB protects specifically KRAS-mutant lung cancer cells from ferroptosis, mainly of the plasma membrane, by maintaining SLC7A11-mediated glutathione metabolism 24

In contrast, the numbers of Kupffer cells in obese SerpinB2 +/+ and SerpinB2 / mice were similar (Supplementary Fig

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This absorption is almost entirely dependent on intrinsic factor binding to vitamin B12