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Lipids Astrocytes are well known for their ability to metabolize exogenous fatty acids via mitochondrial -oxidation and to subsequently utilize fatty acid-derived acetyl-CoA for oxidation to CO 2 in the mitochondrial citric acid cycle or for ketogenesis, both in culture [147, 181,182,183,184] and in brain slices [185, 186]

Similarly, metabolomic profiling of blood and CSF in patients, alongside microbiome data, can identify which microbial metabolites truly cross into the brain and affect pathways like amyloid deposition or axonal integrity

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10.1126/science.8171325 Science 176 VriendJ.ReiterR

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Moreover, as active oxides in the body, lipid peroxidation can also damage other macromolecules