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Circulation 116 (8), 944953

Christopher Shade, Ph

The assessment of ototoxicity is necessary for medications delivered via the otic route that are anticipated to affect the middle or inner ear during clinical application (Pasdelou et al

Front Pharmacol 15

For example, resveratrol (plant-derived phytoalexin) treatment triggers a strong signal for autophagy (p62 accumulation) through JNK activation leading to death in imatinib-resistant chronic myelogenic leukemia cells (CML) [369, 370]