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Metformin has been demonstrated to prevent renal tubulointerstitial fibrosis (181) by addressing the reduced energy supply resulting from impaired fatty acid oxidation (FAO) in proximal tubular cells

Inject aliquots into HPLC to separate unbound and bound fractions

Severe mitochondrial dysfunction and decreases in the activities of several liver enzymes, including complex I, complex II, complex III, complex IV, and aconitase, were observed in patients with copper overload