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Furthermore, the TNF-induced mRNA expression of the NFKB1 and RELA genes which encode the two NF-B subunits (NF-B p50 and NF-B p65, respectively) was also reduced by luteolin treatment, suggesting that luteolin reduces pro-inflammatory cytokine production by decreasing NF-B induction (Weng et al., 2014)

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Volcano plot analysis confirmed a significant downregulation of choline and acetic acid, along with an upregulation of L-leucine, 3-hydroxybutyric acid, and L-proline levels in female patients compared to control subjects ( Fig

10.1016/j.actbio.2022.02.025