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When AhR was bound to its agonist, AHR was dissociated from the protein complex and translocated to the nucleus, where it interacted with aryl hydrocarbon receptor nuclear transporter (ARNT) to form a dimer, and activated transcription of target genes by binding to specific enhancer sequences in the regulatory regions of target genes, such as the aryl hydrocarbon receptor response element on the cytochrome P450 Family 1 subfamily B member 1 (CYP1B1) promoter (78)

Moreover, copper influences lipid signaling by modulating the activity of phosphodiesterase PDE3B, an enzyme that hydrolyzes cyclic adenosine monophosphate (cAMP) to regulate lipolysis [122]

More, PhD Professor, Center for Drug Design expand_more library_books References (1) Swati S

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10.1038/nature09513 Nature 93 DanemanR.ZhouL.AgalliuD.CahoyJ

BSO treatment alone, which reduced GSH by 65 and 85% in inner hair cells and outer hair cells respectively, did not cause any significant cell death