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Patients with sickle cell disease may develop ulcers around the ankle

The processing of the Gag and Gag-Pol polyproteins releases the matrix, capsid, nucleocapsid, p6, protease, reverse transcriptase, and integrase proteins.[47] Protease Inhibitors The HIV protease inhibitors are structurally complex molecules that bind to the active site of HIV protease and inhibit protease enzyme activity (Figure 15).[44,45] The HIV protease inhibitors disrupt the normal Gag and Gag-Pol polyprotein processing, causing the arrest of the normal maturation process, which thereby prevents infection of new cells

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Figure 6 illustrates how IRBP immunization, followed by EAU induction, enhanced the proliferation of IRBP-specific lymphocytes