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Most nociceptive TRP channels are predominantly expressed in peripheral sensory neurons, but there is also a significant expression in the central nervous system and other tissue and cell types (i.e., keratinocytes, vascular endothelial cells, bladder epithelial cells, fibroblasts and human dental pulp) (Mickle et al., 2+ entry in hippocampal and DRG neurons (Kahya et al., 2015)

TB-500: A synthetic fragment of Thymosin Beta-4, a naturally occurring protein studied for its effects on cellular migration, differentiation, and promoting angiogenesis (the formation of new blood vessels)

10.1136/gut.52.8.1215 Gut 4 BaiY.MengL.HanL.JiaY.ZhaoY.GaoH.et al (2019)

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2000;83(S1):S1438

Results Pediatric and Adult Enteroid Monolayers Exhibit Distinct Cell Morphology and Maturation Features To mechanistically interrogate the physiological effects of human breast milk in the pediatric gut, differentiated (villus-like) enteroid monolayers were established from duodenal biopsies of healthy 2- and 5-year-old children who underwent diagnostic endoscopy (Figure 1A) at The Johns Hopkins Hospital, using methods previously described (Noel et al., 2017