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Description

Single doses over 150-200 mg/kg in healthy children pose significant risk of hepatotoxicity

Reasons for the different results may include the limited sample sizes, the assays for detection, different stages of the disease, and the difference between local and systemic states of oxidative stress

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Another case of LS caused by an MT-ND1 mutation demonstrated decreased background activity, multifocal epileptic discharges, and significant irregularity (39)