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The 22-nt long mature miRNA strand obtained from the intermediate duplex is then loaded into the Argonaute-containing RNA-induced silencing complex (RISC) and target mRNA molecules by miRNA:mRNA sequence complementarity and negatively affects gene expression either through mRNA cleavage and degradation via the perfect base-pairing with target mRNA or translation repression via imperfect complementation with 3UTR of target mRNA (Smith-Vikos and Slack, 2012)

Anti-inflammatory effects of sodium butyrate on human monocytes: potent inhibition of IL-12 and up-regulation of IL-10 production

doi: 10.1104/pp.105.065649 64 OppenheimerD

Expression analysis of GPX4 mRNA in DLBCL To determine whether GPX4 is overexpressed at the protein level or at the mRNA level in DLBCL, we first evaluated the GPX4 protein expression level in 48 DLBCL cases by immunohistochemistry and, depending on the results, divided into two groups, GPX4-positive and GPX4-negative group, according to the criteria described above

Acta 1830 , 32673288 (2013)

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