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87 Alternatively, hyperexcitable small fiber neurons in PDPN might be more susceptible to bioenergetic failure, increasing distal nerve fiber degeneration

Hypothyroidism is often a cause of Vitamin B12 deficiency, arising from the reduced absorption of B12, poor utilisation of the liver, and general organ disfunction associated with hypothyroidism, and sometimes by dietary insufficiency of B12 (particularly in the case of a vegetarian diet)

Different mechanisms, different side-effect profiles

Stage 1: Depleted Stores (Often Asymptomatic) Liver B12 stores decline

That causes minor bruising that resolves within a few days

Always consult a licensed healthcare professional before starting any new health protocol, follow institutional and jurisdictional safety regulations, and verify the legal status of any compound in your region