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It is well-tolerated in animal and early clinical studies, even at multi-milligram doses [12]

[DOI] [PMC free article] [PubMed] [Google Scholar] 20.Ros-Ros K.L., Montilla A., Olano A., Villamiel M

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Engert V, Pruessner JC

The serum HBV-DNA and HBsAg levels in HBV transgenic mice significantly decreased, with HBsAg expression levels approaching zero and HBV-DNA replication levels dropping to 50% of the original levels