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While the direct relationship between autosis and BPD remains unclear, the autophagy-mitochondrial axis warrants attention: (1) Autophagy dysregulation (e.g., via Rubicon-Beclin1-Na + /K + -ATPase pathway disruption): may promote cell death by impairing mitochondrial quality control (Li Y

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Notably, immune senescence is particularly detrimental to the respiratory system of older adults, who are easy targets for exogenous infections (162)

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