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This is because each polyamide can only target a subset of AR-dependent genes, instead of simultaneously targeting all AR-dependent genes important for disease progression

This reduction was more evident in patients who retained vitamin D levels at 100 nmol/L at 52 weeks [55]

Valproic acid is fully ionized into valproate at the physiologic pH of the human body, and valproate is the active form of the drug

Biochem Biophys Res Commun 303:10471052 Oellgaard J, Winther SA, Hansen TS, Rossing P, von Scholten BJ (2017) Trimethylamine N -oxide (TMAO) as a new potential therapeutic target for insulin resistance and cancer