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Its advantages in overcoming drug resistance are: 1) Oral formulations are delivered through albumin binding or nanocarriers to avoid insufficient uptake caused by low hENT1 expression (D et al., 2025), and in pancreatic cancer models, the efficacy is 30% higher than that of intravenous formulations

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Rather, restoring NADPH levels through supplementing with ordinary thiamine and supporting the glutathione system via other measures might be advised before starting with TTFD

Trop J Nat Prod Res 7:33763387 [Google Scholar] Diaconu M, Soreanu G, Balan CD, Buciscanu II, Maier V, Cretescu I (2023) Study of Spirulina platensis (Arthrospira) development under the heavy metals influence, as a potential promoter of wastewater remediation

Data from adipocyte culture systems demonstrate insulin-stimulated Ras farnesylation drives both adipogenic differentiation programs and glucose transport mechanisms through extracellular signal-regulated kinase 1/2 (ERK1/2) activation (194, 195)