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Description

Their status is closely linked to their mechanisms

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They are periodically replaced by a single layer of basal keratinocytes, which proliferate constantly and give birth to cells that ascend toward the skins surface

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On neutrophil activation, the PPP is promoted, alongside glycolysis, to supply NADPH for antibacterial activity

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GDF15 regulates the metabolic pathways of macrophages, acquiring an anti-inflammatory function dependent on oxidative phosphorylation, reducing the expression of pro-inflammatory factors, and decreasing the infiltration of monocytes and neutrophils into the liver, thereby alleviating liver inflammation [174, 175]

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