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The mitochondrial accumulation of LC3 puncta after treatment with Complex I inhibitor rotenone indicate mitophagy is increased by mitochondrial stress (Zhou et al., 2011)

These effects were not reproduced in 3-AR knockout mice, suggesting that the 3-AR plays a key role in the compounds chronic metabolic effects (Heffernan et al

BMJ, 332(7538), 385- 393

A friend in the research space had been following the Retatrutide clinical trial results closely and sent me a breakdown of the Phase 2 data

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Selenium, for example, is a mineral that helps the body produce an enzyme called glutathione peroxidase