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Loss of normal farnesylation disrupts IR trafficking dynamics and surface expression patterns through altered endosomal sorting mechanisms, contributing to cellular insulin resistance (203)

McAleer MF, Smith GL, Smith BD, Swisher SG , Ajani J, Komaki R, Cox JD, Buchholz TA

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Crit Rev Biochem Mol Biol 49(4):294303

In addition to direct damage and oxygen-free radical impact on lung tissue, radiation can induce fibrotic reactions in the lungs, leading to structural and functional changes in non-tissues