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Protocol 3: comprehensive stack (severe or chronic herniations) Goal: Maximum regenerative support for severe herniations, chronic disc degeneration, or cases being managed alongside other treatments to avoid surgery

Notably, comparisons of these analogs are limited because efruxifermin and pegbelfermin have been evaluated in patients with confirmed NASH, while BIO89-100 has been studied in patients with less severe NAFLD

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Journal of American Medical Association

Its antioxidant effect likely protects the tissues from areca nut-induced oxidative damage, which is known to contribute to fibroblast activation

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