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doi: 10.1016/j.biopha.2022.113139

Approximately 17% of first opioid overdoses observed over the entire study period (5 to 11 years, depending on the study site) were fatal

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In contrast, although non-antimicrobial sulfonamides are sulfur-based, these medications have a different chemical structure [5]

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33,34 JNK translocates to mitochondria, binds to SH3 homologyassociated Brutons tyrosine kinase (BTK) binding protein (Sab) on the mitochondrial membrane, and subsequently inactivates a proto-oncogene tyrosine-protein kinase (Src) in mitochondria, eventually leading to the dysfunction of the ETC and the increased release of reactive oxygen species (ROS)