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In the aforementioned study from our group, adult mice with partial IGF-1 also displayed decreased expression of genes involved in lipid metabolism (ATP-citrate lyase, acetyl-CoA acyltransferase 1B, acetyl-CoA acetyltransferase 1) and cholesterol synthesis and transport (Both HMG-CoA reductase and synthase, LDL-related protein 1, proprotein convertase subtilisin/Kesin type 9), resulting in dyslipidaemia

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What we do not know Several questions remain unanswered: Does prolonged amylin receptor agonism produce any adaptive changes in receptor expression or sensitivity that could alter efficacy or safety over years

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10.1038/bcj.2015.32 68