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Artemisinin significantly reduced p38 MAPK phosphorylation of VEGF-C in a dose-dependent manner and had a significant inhibitory effect on tumor lymphatic microvessel density in the peritumor area, ultimately increasing the survival of lung cancer mice (Wang et al., 2008)

et al.: KPV as an MSH fragment retains potent antiinflammatory activity without melanotropic side effects FASEB Journal (2003) Brzoska T

GSTM1 is also the primary enzyme handling oxidative stress byproducts from CYP1A1/CYP1B1-mediated estrogen metabolism including reactive oxygen species generated during the hydroxylation reactions themselves

Hepatology 1999;30:79-83

It can trigger autoimmunity and antibodies against intrinsic factor /parietal cells, leading to pernicious anemia (Allakky, 2023)

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