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A very high dose of 30 g shows little difference between males and females

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These bioactive molecules specifically target and inhibit the cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) enzymatic pathways

Additionally, the authors acknowledge the general positive bias of the published results, the lack of replicative validation studies, and the resulting risk of overestimating treatment efficacy in preclinical models that would provide confidence for the current findings and improve translational significance

Elegant review studies are already published elsewhere (Jiang and Cadenas, 2014