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The Dialcat Consortium Article: PLOS ONE

10.3389/fphar.2022.873646 237 YeS.MaoB.YangL.FuW.HouJ

Tested in WB, IHC, IP applications

Wang, J., Zhang, A., Ye, M

Freezing a liquid solution causes sharp ice crystals to form

Hence, it is logical to hypothesize that masking of the terminal NH 2 group by making a labile chemical derivative of INH, i.e., a derivative which can release INH back when exposed to biofluid in gut or blood (owing to hydrolytic activity of esterase/amidase) can limit known metabolic biotransformations of INH (Figure 6)