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Since up-regulation of SCN3A has been demonstrated to enhance neuronal excitability and contribute to the development of epilepsy, the reduction of SCN3A expression by VPA due to its promotion on methylation may underlie the anti-epileptic effect of VPA

References Wen PY, Reardon DA

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Selectively sending fluid studies, for example when prompted by new symptoms, appears to have higher diagnostic yield for SBP, particularly in patients with existing indications for SBP prophylaxis

Monitoring sodium is recommended with administration of multidose activated charcoal, as is utilizing IV fluids to minimize the risk of hypernatremia

Methods: DNA was obtained from participants with BA enrolled in the NIH-supported NIDDK ChiLDReN consortium, a prospective study of cholestatic infants from 14 sites in North America