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Several observations, however, are undisputed: (i) corticosteroids are effective [91], (ii) superpotent topical corticosteroids applied in large quantities (initially 40 g/day) on the entire body are as effective as oral predniso(lo)ne at a starting dose of 0.5 mg/kg/day [91], (iii) predniso(lo)ne at a starting dose of 1.0 mg/kg/day is associated with a higher number of severe adverse events and increased mortality compared with predniso(lo)ne at a starting dose of 0.5 mg/kg/day [91], (iv) doxycycline 200 mg/day is effective, although significantly less than predniso(lo)ne at a starting dose of 0.5 mg/kg/day [92], (v) dapsone 1.5 mg/kg/day is effective and has a higher corticosteroid-sparing potential than azathioprine 1.52.5 mg/kg/day [93], and (vi) IVIG 2 g/kg body weight/day is effective [94]

At present, there is still no high-quality randomized controlled trial confirming the efficacy of VLEKT in psoriasis, which highlights the need for more robust clinical evidence (195)

& Mueller, S

Ganoderma lucidum polysaccharide peptide attenuates skin flap ischemia-reperfusion injury in a thioredoxin-dependent manner

23.0% LTC (77.0% LTFU) and 4.1% Tx initiated in SOC

Environ Toxicol 38:29522966