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Serum acetaldehyde concentrations were determined using an Acetaldehyde Assay Kit (ab112113, Abcam, Cambridge, UK) employing an enzymatic colorimetric method

Additional efforts have been made to pursue concurrent treatment with TMZ and pembrolizumab, an anti PD-1 antibody, as a strategy to delay immune exhaustion (NCT06556563) [148]

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Many identified metabolites, such as those containing sulfur and phenol, are known to be toxic to enterocytes, disrupt intercellular tight junctions (TJ), and stimulate bacterial translocation, all of which support this idea (Cox et al., 2014)

Some patients come weekly during a recovery or loading phase

Sundaraneedi, M