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Therapeutic influence on important targets associated with chronic inflammation and oxidative stress in cancer treatment

Impaired mitophagy triggers NLRP3 inflammasome activation during the progression from nonalcoholic fatty liver to nonalcoholic steatohepatitis

McHugh, D., Durn, I

F.EquitaniF.DeVitoR.ValentiL.et al (2011)

doi: 10.1016/s0025-6196(11)60669-1 128 DaSilva-ArnoldSJamesJLAl-KhanAZamudioSIllsleyNP

To determine which cell type(s) derived from HSCs overexpressing SIRT3 alleviate aging-associated tissue functional decline, T cells or myeloid cells isolated from 2-year-old mice reconstituted with HSCs from either Mx1-T3 or Mx1-Cre control mice were transferred to young WT recipients (Fig