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ALA, a precursor to omega-3 fatty acids, possesses anti-inflammatory properties [34] and may modulate mitochondrial function [35]

The oxidation of PUFA-PE by lipoxygenase (LOX) leads to cellular ferroptosis [71] (Fig

In this work we compared these two structures, particularly their H sites, and analyzed the effect of GSH binding on the stability and mobility of both enzymes through MD simulations