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Finally, given the pragmatic nature of the proposed trial, the decision was taken to include consecutive patients seeking medical help at the participating centres, thus ensuring the enrolment of subjects similar to those that would be seen in normal clinical practice

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High Vitamin B12 Levels May Be a Biomarker of Cancer A 2013 study published in the Journal of the National Cancer Institute reported that elevated serum cobalamin (vitamin B12) levels were associated with: 5 Subsequent cancer diagnoses, particularly within the first year of follow-up An increased risk of smoking-related, hematological (blood-related), and alcohol-related cancers Researchers concluded that elevated vitamin B12 levels may serve as a potential biomarker for cancer