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While cystine is generally considered the rate-limiting amino acid for GSH synthesis [47], glutamate also plays a crucial role in GSH production, especially in cancer cells with a high demand for GSH

Safety assessments included treatment-emergent adverse events (AEs), vital signs (BP and HR), bodyweight, physical examinations and laboratory parameters

Induced cultivations were kept on separate incubator from uninduced ones to avoid any effect of the highly volatile cyclohexanone

It remains unclear whether GAD is involved in SLMVs transport to the plasma membrane, in analogy to GABAergic neurons (see also Section 3.3)

the NF-kB pathway) independent of ligand engagement (121123)